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Papers of the Week

Papers: 6 May 2023 - 12 May 2023

Basic Science

Animal Studies, Genetics, Human Studies, In Vitro Studies, Molecular/Cellular, Neurobiology

Neuropathic Pain

2023 May 05

CNS Neurosci Ther


Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner.


Xie L, Zhang M, Liu Q, Wei R, Sun M, Zhang Q, Hao L, Xue Z, Wang Q, Yang L, Wang H, Pan Z


Nerve injury-induced maladaptive changes in gene expression in the spinal neurons are essential for neuropathic pain genesis. Circular RNAs (ciRNA) are emerging as key regulators of gene expression. Here, we identified a nervous-system-tissues-specific ciRNA-Kat6 with conservation in humans and mice. We aimed to investigate whether and how spinal dorsal horn ciRNA-Kat6b participates in neuropathic pain.