Diterpenoid DGT alleviates atopic dermatitis-like responses in vitro and in vivo via targeting IL-4Rα.
Authors
Gao J, Li D, Feng Z, Zhu X, Yang F, Zhang B, Hu M, Wang Y, Feng H, Yu Y, Xie Q, Chen Z, Li Y
Abstract
Atopic dermatitis is a common chronic inflammatory skin disease characterized by relapsing eczema and intense itch. DGT is a novel synthetic heterocyclic diterpenoid derived from plants. Its therapeutic potential and mechanism(s) of action are poorly understood.
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