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Papers of the Week
Development of a Novel Rat Knee Osteoarthritis Model Induced by Medial Meniscus Extrusion.
Authors
Fukui D, Nishiyama D, Yamanaka M, Tamai H, Nishio N, Kawakami M, Yamada HAbstract
The medial meniscus extrusion (MME) is associated with increased stress on the knee joint, which leads to cartilage degeneration. To evaluate the etiology of knee osteoarthritis, it is extremely important to create animal models of the disease that more closely resemble actual clinical conditions in terms of symptomatology, molecular biology, and histology. This study aimed to create a clinically relevant model of MME in rats.