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Papers of the Week


Papers: 17 Jun 2023 - 23 Jun 2023

RESEARCH TYPE:
Review


Genetics, Human Studies

PAIN TYPE:
Abdominal/Pelvic Pain


2023 Jun 22


J Gastrointestin Liver Dis


37345594


32


2

Contribution of MicroRNAs in the Development of Irritable Bowel Syndrome Symptoms.

Authors

Thomas Dupont P, Izaguirre-Hernández IY, Remes-Troche JM

Abstract

Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder defined by disturbances in bowel habits and abdominal pain, in the absence of known organic pathology that affects between 5 to 10% of healthy populations. Despite improvements in detection and treatment, the pathogenesis of IBS has not been clarified. Several microRNAs (miRNAs) are involved in the pathogenesis of IBS through increased intestinal permeability, inflammation, and modulation of visceral hyperalgesia, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the role of miRNAs in the development of IBS symptoms and the possibility to use them as therapeutic targets to mitigate symptoms in IBS.