I am a
Home I AM A Search Login

Papers of the Week

Papers: 13 April 2024 - 19 April 2024

2024 Apr 11

Brain Res Bull


Combining Fecal 16S rRNA Sequencing and Spinal Cord Metabolomics analysis to explain the modulatory effect of PPARα on Neuropathic Pain.


Wu ZJ, Zhao YY, Hao SJ, Dong BB, Zheng YX, Liu B, Li J


Existing evidence suggests that the composition of the gut microbiota is associated with neuropathic pain (NP), but the mechanistic link is elusive. Peroxisome proliferator-activated receptor α (PPARα) has been shown to be a pharmacological target for the treatment of metabolic disorders, and its expression is also involved in inflammatory regulation. The aim of this study was to investigate the important modulatory effects of PPARα on gut microbiota and spinal cord metabolites in mice subjected to chronic constriction injury.