Chronic nicotine exposure elicits pain hypersensitivity through activation of dopaminergic projections to anterior cingulate cortex.
Authors
Chen D, Shen L, Zhang YZ, Kan BF, Lou QQ, Long DD, Huang JY, Zhang Z, Hu SS, Wang D
Abstract
Cigarette smoking is commonly reported among chronic pain patients in the clinic. Although chronic nicotine exposure is directly linked to nociceptive hypersensitivity in rodents, underlying neurobiological mechanisms remain unknown.
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