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Papers of the Week


Papers: 11 Jan 2025 - 17 Jan 2025


2025 Jan


CNS Neurosci Ther


39817595


31


1

CHOP-Mediated Disruption of Hippocampal Synaptic Plasticity and Neuronal Activity Contributes to Chronic Pain-Related Cognitive Deficits.

Authors

Meng Q, Su S, Lei L, Zhang Y, Duan J, Ren X, Song Y, Hu X, Chen S, Zang W, Zhang Z, Cao J

Abstract

Endoplasmic reticulum (ER) stress-induced protein homeostasis perturbation is a core pathological element in the pathogenesis of neurodegenerative diseases. This study aims to clarify the unique role played by C/EBP homologous protein (CHOP) as a biomarker of the unfolded protein response (UPR) in the etiology of chronic pain and related cognitive impairments following chronic constrictive nerve injury (CCI).