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Papers of the Week


Papers: 20 Jul 2024 - 26 Jul 2024


2024 Jul 17


Comput Methods Programs Biomed


39038390


255

Biophysical essentials – A full stack open-source software framework for conserved and advanced analysis of patch-clamp recordings.

Authors

Zimmermann D, Kress M, Zeidler M

Abstract

Patch-Clamp recordings allow for in depth electrophysiological characterization of single cells, their general biophysical properties as well as characteristics of voltage- and ligand-gated ionic currents. Different acquisition modes, such as whole-cell patch-clamp recordings in the current or voltage clamp configuration, capacitance measurements or single channel recordings from cultured cells as well as acute brain slices are routinely performed for these purposes. Nevertheless, multipurpose transparent and adaptable software tools to perform reproducible state-of-the-art analysis of multiple experiment types and to manage larger sets of experimental data are currently unavailable.