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Papers of the Week

Papers: 18 May 2024 - 24 May 2024

2024 May 17

Osteoarthritis Cartilage


Associations of Pain Sensitivity and Conditioned Pain Modulation with Physical Activity: Findings from the Multicenter Osteoarthritis Study (MOST).


Lee S, Neogi T, Mcginley B, Wang N, Frey-Law L, Torabian KA, Aoyagi K, Stefanik JJ, Carlesso LC, Hausdorff JM, Gazit E, Segal NA, Lewis CE, Nevitt MC, Kumar D


Individuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active, and alterations of facilitatory and inhibitory nociceptive signaling are common in this population. Our objective was to examine the association of these alterations in nociceptive signaling with objective accelerometer-based measures of physical activity in a large observational cohort.