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Papers of the Week
Alcohol withdrawal and pain: Peripheral mechanisms join central circuits.
Authors
Neugebauer V, Ponomarev IAbstract
Negative affective aspects of alcohol withdrawal and pain involve converging brain circuits. In this issue of Neuron, Son et al. identify a peripheral mechanism of an alcohol-withdrawal-induced headache-like condition, which is centered on mast-cell-specific receptor MrgprB2 activated by corticotropin-releasing factor (CRF) in dura mater to drive nociception.