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Papers of the Week

Papers: 16 Dec 2023 - 22 Dec 2023

2023 Dec 14



A Randomized Controlled Phase 2 Dose-Finding Trial to Evaluate the Efficacy and Safety of Camostat in the Treatment of Painful Chronic Pancreatitis: The TACTIC Study.


Hart PA, Osypchuk Y, Hovbakh I, Shah RJ, Nieto J, Cote GA, Avgaitis S, Kremzer O, Buxbaum J, Inamdar S, Fass R, Phillips RW, Yadav D, Ladd AM, Al-Assi MT, Gardner T, Conwell DL, Irani S, Sheikh A, Nuttall J


Chronic pancreatitis (CP) causes an abdominal pain syndrome associated with poor quality of life (QOL). We conducted a clinical trial to further investigate the efficacy and safety of camostat, an oral serine protease inhibitor, which has been used to alleviate pain in CP.