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Papers of the Week
A novel small molecule, AS1, reverses the negative hedonic valence of noxious stimuli.
Authors
Esancy K, Conceicao LL, Curtright A, Tran T, Condon L, Lecamp B, Dhaka AAbstract
Pain is the primary reason people seek medical care, with chronic pain affecting ~ 20% of people in the USA. However, many existing analgesics are ineffective in treating chronic pain, while others (e.g., opioids) have undesirable side effects. Here, we describe the screening of a small molecule library using a thermal place aversion assay in larval zebrafish to identify compounds that alter aversion to noxious thermal stimuli and could thus serve as potential analgesics.