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Papers of the Week
5-HT receptor agonism induces mitochondrial biogenesis and increases cellular function in brain microvascular endothelial cells.
Authors
Scholpa NE, Simmons EC, Thompson AD, Carroll SS, Schnellmann RGAbstract
Vascular and mitochondrial dysfunction are well-established consequences of multiple central nervous system (CNS) disorders, including neurodegenerative diseases and traumatic injuries. We previously reported that 5-hydroxytryptamine 1F receptor (5-HTR) agonism induces mitochondrial biogenesis (MB) in multiple organ systems, including the CNS.