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Papers of the Week


2023 Jan 26


Clin Exp Dermatol

Treatment of dissecting cellulitis of the scalp with tumor necrosis factor inhibitors: a retrospective multicenter study.

Authors

Alzahrani M, Coste V, Konstantinou M P, Reguiai Z, Villani A, Hotz C, Viguier M, Pruvost-Balland C, Dupuy A, Wolkenstein P, Brun A, Aubin F, Gallais Sérézal I
Clin Exp Dermatol. 2023 Jan 26.
PMID: 36702808.

Abstract

Although retinoids are considered as the most effective treatment, management of dissecting cellulitis of the scalp (DCS) is often challenging. A multicenter retrospective study was conducted to evaluate the efficacy of anti-TNF agents in treating DCS after failure of other conventional treatments. Twenty-six patients were included. After a mean treatment duration of 19 ± 21 months, the mean PGA score decreased by 56% as the number of abscesses (-89%), the number of inflammatory nodules (-70%), the mean NRS score for pain severity (-68%) and the mean DLQI (-29%). This study confirms the efficacy of anti-TNF agents in treating DCS patients resistant to conventional therapies.