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Papers of the Week

Papers: 14 Jan 2023 - 20 Jan 2023

Human Studies

2023 Jan 13

Rheumatology (Oxford)

A Phase II randomised controlled trial of oral prednisolone in early diffuse cutaneous systemic sclerosis (PRedSS).


Griffiths-Jones DJ, Garcia Y S, Ryder DW, Pauling JD, Hall F, Lanyon P, Bhat S, Douglas K, Gunawardena H, Akil M, Anderson M, Griffiths B, Del Galdo F, Youssef H, Madhok R, Arthurs B, Buch M, Fligelstone K, Zubair M, Mason JC, et al.
Rheumatology (Oxford). 2023 Jan 13.
PMID: 36637209.


Although the painful and disabling features of early diffuse cutaneous systemic sclerosis (dcSSc) have an inflammatory basis and could respond to corticosteroids, corticosteroids are a risk factor for scleroderma renal crisis. Whether or not they should be prescribed is therefore highly contentious. Our aim was to examine safety and efficacy of moderate dose prednisolone in early dcSSc.