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Papers of the Week

Papers: 7 Jan 2023 - 13 Jan 2023

2022 Dec

Ann Transl Med



Association of genotype predicted phenotypes with oxycodone requirements and side effects in children undergoing surgery.


Merchant S, Prows CA, Yang F, Ding L, MacDonald J, Zhang X, Sadhasivam S, Garcia V, Sturm P, Chidambaran V
Ann Transl Med. 2022 Dec; 10(23):1262.
PMID: 36618804.


Oxycodone is a commonly used oral opioid in children for treating postoperative pain. Highly polymorphic gene metabolizes oxycodone into its more potent metabolite, oxymorphone. We hypothesized that altered activity due to polymorphisms will influence oxycodone requirements {relative oxycodone use [oxycodone morphine equivalents (MEq)/total MEq] to maintain analgesia} (primary outcome) and risk for oxycodone induced side-effects such as respiratory depression (RD) and emesis (secondary outcomes). We also explored the influence of genotype availability and provider guidance on oral opioid prescription patterns.