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Papers of the Week

Papers: 7 Jan 2023 - 13 Jan 2023

Animal Studies, Pharmacology/Drug Development

2023 Jan 05

Tissue Cell


Synergistic role of resveratrol and exercise training in management of diabetic neuropathy and myopathy via SIRT1/NGF/GAP43 linkage.


Ghoweba R E, Khowailed A A, Aboulhoda B E, Rashed L A, Selmy A
Tissue Cell. 2023 Jan 05; 81:102014.
PMID: 36621294.


Oxidative stress also plays an important role in the pathogenesis of diabetic neuropathy (DN). Both resveratrol (RES) and exercise (EX) have potent anti-oxidative benefits. Low levels of nerve growth factor (NGF) and SIRT1 (a member of sirtuin family) have been reported in patients with DN. The current study has been designed to investigate the role of serum NGF and SIRT1 on DN-induced hyperalgesia and motor incoordination and to evaluate the possible protective role of RES and/or EX.