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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Synergistic role of resveratrol and exercise training in management of diabetic neuropathy and myopathy via SIRT1/NGF/GAP43 linkage.

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Papers: 7 Jan 2023 - 13 Jan 2023


Animal Studies, Pharmacology/Drug Development


2023 Jan 05


Tissue Cell


http://www.ncbi.nlm.nih.gov/pubmed/36621294?dopt=Abstract


81

Synergistic role of resveratrol and exercise training in management of diabetic neuropathy and myopathy via SIRT1/NGF/GAP43 linkage.

Authors

Synergistic role of resveratrol and exercise training in management of diabetic neuropathy and myopathy via SIRT1/NGF/GAP43 linkage.
Ghoweba R E, Khowailed A A, Aboulhoda B E, Rashed L A, Selmy A
Tissue Cell. 2023 Jan 05; 81:102014.
PMID: 36621294.

Abstract

Oxidative stress also plays an important role in the pathogenesis of diabetic neuropathy (DN). Both resveratrol (RES) and exercise (EX) have potent anti-oxidative benefits. Low levels of nerve growth factor (NGF) and SIRT1 (a member of sirtuin family) have been reported in patients with DN. The current study has been designed to investigate the role of serum NGF and SIRT1 on DN-induced hyperalgesia and motor incoordination and to evaluate the possible protective role of RES and/or EX.
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