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Papers of the Week

2022 Dec 31

Biomed Pharmacother


Beta-blocker treatment of patients with atrial fibrillation attenuates spontaneous calcium release-induced electrical activity.


Jiménez-Sábado V, Casabella-Ramón S, Llach A, Gich I, Casellas S, Ciruela F, Chen WSR, Guerra JM, Ginel A, Benítez R, Cinca J, Tarifa C, Hove-Madsen L
Biomed Pharmacother. 2022 Dec 31; 158:114169.
PMID: 36592495.


Atrial fibrillation (AF) has been associated with excessive spontaneous calcium release, linked to cyclic AMP (cAMP)-dependent phosphorylation of calcium regulatory proteins. Because β-blockers are expected to attenuate cAMP-dependent signaling, we aimed to examine whether the treatment of patients with β-blockers affected the incidence of spontaneous calcium release events or transient inward currents (I).