Browse by Audience
Skip to content
Papers of the Week
Beta-blocker treatment of patients with atrial fibrillation attenuates spontaneous calcium release-induced electrical activity.
Abstract
Atrial fibrillation (AF) has been associated with excessive spontaneous calcium release, linked to cyclic AMP (cAMP)-dependent phosphorylation of calcium regulatory proteins. Because β-blockers are expected to attenuate cAMP-dependent signaling, we aimed to examine whether the treatment of patients with β-blockers affected the incidence of spontaneous calcium release events or transient inward currents (I).