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Papers of the Week

2023 Jan-Feb

In Vivo



Age-related Changes in Trigeminal Ganglion Macrophages Enhance Orofacial Ectopic Pain After Inferior Alveolar Nerve Injury.


Fujiwara S, Urata K, Oto T, Hayashi Y, Hitomi S, Iwata K, Iinuma T, Shinoda M
In Vivo. 2023 Jan-Feb; 37(1):132-142.
PMID: 36593019.


The ectopic pain associated with inferior alveolar nerve (IAN) injury has been reported to involve macrophage expression in the trigeminal ganglion (TG). However, the effect of age-related changes on this abnormal pain conditions are still unknown. This study sought to clarify the involvement of age-related changes in macrophage expression and phenotypic conversion in the TG and how these changes enhance ectopic mechanical allodynia after IAN transection (IANX).