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Papers of the Week

2022 Dec 28

Mol Metab

Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity.


Brazill JM, Shin D, Magee K, Majumdar A, Shen IR, Cavalli V, Scheller EL
Mol Metab. 2022 Dec 28:101664.
PMID: 36586433.


Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when and where mTOR activation mediates these effects, limiting options for therapeutic intervention. The objective of this study was to isolate the role of constitutive mTOR activation in Nav1.8-expressing peripheral neurons in the onset of diet-induced obesity, bone loss, and metabolic disease.