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Papers of the Week

2022 Dec 24

BMC Musculoskelet Disord



Randomized, double-blind, noninferiority study of diclofenac diethylamine 2.32% gel applied twice daily versus diclofenac diethylamine 1.16% gel applied four times daily in patients with acute ankle sprain.


Yin F, Ma J, Xiao H, Ao R, Zhang F, Li W, Wang W, Zeng P, Lu T, Bariguian Revel F, Araga M, Patel S, Moreira S, Zhang J, Zhang W
BMC Musculoskelet Disord. 2022 Dec 24; 23(1):1125.
PMID: 36566202.


Diclofenac diethylamine (DDEA) gel has demonstrated efficacy for treatment of ankle sprains in both the 1.16% four-times-daily (QID) and 2.32% twice-daily (BID) formulations. The objective of this study was to compare, for the first time, the efficacy of DDEA 2.32% gel BID and DDEA 1.16% gel QID.