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Papers of the Week

2022 Dec 14

Br J Anaesth

High-dose steroid in low pain responders undergoing total knee arthroplasty: a randomised double-blind trial.


Nielsen NI, Kehlet H, Gromov K, Troelsen A, Husted H, Varnum C, Kjærsgaard-Andersen P, Rasmussen LE, Pleckaitiene L, Foss NB
Br J Anaesth. 2022 Dec 14.
PMID: 36526481.


Postoperative pain after total knee arthroplasty (TKA) is a continuing problem despite optimised multimodal analgesia. Previous studies have shown preoperative glucocorticoids to reduce postoperative pain, but knowledge about specific doses and effects in specific patient groups is lacking.