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Papers of the Week

Papers: 10 Dec 2022 - 16 Dec 2022

Pharmacology/Drug Development

2022 Dec 15

Br J Pharmacol

Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons.


Sun P-Y, Li H-G, Xu Q-Y, Zhang Z, Chen J-W, Shen Y-H, Qi X, Lu J-F, Tan Y-D, Wang X-X, Li C-X, Yang M-Y, Ma Y-Z, Lu Y, Xu T-L, Shen J-W, Li W-G, Guo Y-F, Yao Z-R
Br J Pharmacol. 2022 Dec 15.
PMID: 36521846.


Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disease that relies on neuro-immune communication while neuronal mechanism-based therapeutic attempts remain lacking. We sought to investigate the efficacy of intravenous lidocaine therapy on AD and underlying neuro-immune mechanism.