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Papers of the Week

2022 Dec 09

Pilot Feasibility Stud



The PerPAIN trial: a pilot randomized controlled trial of personalized treatment allocation for chronic musculoskeletal pain-a protocol.


Beiner E, Baumeister D, Buhai D, Löffler M, Löffler A, Schick A, Ader L, Eich W, Sirazitdinov A, Malone C, Hopp M, Ruckes C, Hesser J, Reininghaus U, Flor H, Tesarz J
Pilot Feasibility Stud. 2022 Dec 09; 8(1):251.
PMID: 36494768.


The therapy of chronic musculoskeletal pain (CMSP) is complex and the treatment results are often insufficient despite numerous therapeutic options. While individual patients respond very well to specific interventions, other patients show no improvement. Personalized treatment assignment offers a promising approach to improve response rates; however, there are no validated cross-disease allocation algorithms available for the treatment of chronic pain in validated personalized pain interventions. This trial aims to test the feasibility and safety of a personalized pain psychotherapy allocation with three different treatment modules and estimate initial signals of efficacy and utility of such an approach compared to non-personalized allocation.