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Papers of the Week

Papers: 12 Nov 2022 - 18 Nov 2022

Animal Studies


J Pain Res


The Endocannabinoid Analgesic Entourage Effect: Investigations in Cultured DRG Neurons.


Anand U, Pacchetti B, Anand P, Sodergren M H
J Pain Res. 2022; 15:3493-3507.
PMID: 36394060.


The endocannabinoid 2-Arachidonyl glycerol (2-AG) exerts dose-related anti-nociceptive effects, which are potentiated by the related but inactive 2-palmitoyl glycerol (2-PG) and 2-linoleoyl glycerol (2-LG). This potentiation of analgesia and other in vivo measures was described as the "entourage effect". We investigated this effect on TRPV1 signalling in cultured dorsal root ganglion (DRG) nociceptors.