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Papers of the Week

2022 Oct 16

World J Clin Cases



Malignant giant cell tumors of the tendon sheath of the right hip: A case report.


Huang W-P, Gao G, Yang Q, Chen Z, Qiu Y-K, Gao J-B, Kang L
World J Clin Cases. 2022 Oct 16; 10(29):10763-10771.
PMID: 36312472.


Malignant giant cell tumor of the tendon sheath (MGCTTS) is an extremely rare malignant tumor originating from synovial and tendon sheath tissue with highly aggressive biological behavior and a high rate of local recurrence and distant metastasis which should be considered a highly malignant sarcoma and managed aggressively. How to systemically treat MGCTTS remains a challenge. In this case, a patient with MGCTTS suffered a recurrence after 2 surgical resections received adjuvant chemotherapy and radiation therapy, but the treatment outcome remained poor. More clinical trials and better understanding of the biology and molecular aspects of this subtype of sarcoma are needed while novel medicines should be developed to efficiently target particular pathways.