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Papers of the Week


Papers: 8 Oct 2022 - 14 Oct 2022


Human Studies, Pharmacology/Drug Development


2022


Front Neurol


13

Cranial autonomic symptoms and response to monoclonal antibodies targeting the Calcitonin gene-related peptide pathway: A real-world study.

Authors

De Matteis E, Caponnetto V, Casalena A, Frattale I, Gabriele A, Affaitati G, Giamberardino M A, Maddestra M, Viola S, Pistoia F, Sacco S, Ornello R
Front Neurol. 2022; 13:973226.
PMID: 36212640.

Abstract

Cranial autonomic symptoms (CAS), including conjunctival injection, tearing, nasal congestion or rhinorrhea, eyelid edema, miosis or ptosis, and forehead or facial sweating ipsilateral to headache, are often reported by patients with migraine during headache attacks. CAS is a consequence of the activation of the trigeminovascular system, which is the target of monoclonal antibodies acting on the CGRP pathway. Therefore, we hypothesized that patients with CAS might have higher trigeminovascular activation than those without CAS leading to a better response to anti-CGRP treatments.