Papers of the Week

The decreased expression of mu-opioid receptors (MOR) in the amygdala may be a key molecular in chronic post-surgical pain (CPSP). It is known that miR-339-5p expression in the amygdala of a stressed rat model was increased. Analyzed by RNAhybrid, miR-339-5p could target opioid receptor mu 1 () which codes MOR directly. So, the authors hypothesized that miR-339-5p could regulate the expression of MOR via targeting and cause the effects to CPSP.