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Papers of the Week

Papers: 10 Sep 2022 - 16 Sep 2022

Pharmacology/Drug Development

2022 Aug

Transl Androl Urol



Intralesional collagenase for acute phase Peyronie’s disease: a single-center, retrospective cohort study.


Hu M-YY, Sigalos JT, Walker DT, Li MK, Yoffe DA, Modiri N, Gaither TW, Santamaria AJ, Regets KV, Eleswarapu SV, Mills JN
Transl Androl Urol. 2022 Aug; 11(8):1074-1082.
PMID: 36092841.


Peyronie's disease (PD) can be subdivided into acute and chronic phases. Intralesional collagenase has been shown to improve curvature in the chronic phase. Initial clinical trials excluded patients in the acute phase from treatment. Recent studies show comparable results among men in the acute phase. The definition of acute phase varies among existing studies, but it is generally understood to last 12-18 months and is accompanied by penile pain and progression of deformity. We sought to evaluate the safety and efficacy of intralesional collagenase injection therapy during the acute phase of PD using multiple definitions of the acute phase.