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Papers of the Week

Papers: 10 Sep 2022 - 16 Sep 2022

Pharmacology/Drug Development

2022 Sep-Oct

In Vivo



Effect of Systemic Administration of Amitriptyline on Oral Microbes in Rats.


Ninomiya K, Paudel D, Uehara O, Morikawa T, Islam S T, Khurelchuluun A, Ariwansa D, Yoshida K, Matsuoka H, Hajime H, Kayoko F, Nakamura K, Abiko Y
In Vivo. 2022 Sep-Oct; 36(5):2134-2142.
PMID: 36099099.


Amitriptyline is a major tricyclic antidepressant that is also used to relieve chronic orofacial pain. Recently, alterations in gut flora due to various antidepressants have been demonstrated. However, it remains unknown how antidepressants affect the oral environment, including microbiota and innate immunity. The aim of this study was to investigate the effects of amitriptyline on oral microflora and antimicrobial peptides.