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Papers of the Week
The potential interplay between Opioid and the Toll-Like Receptor 4 (TLR-4).
Authors
Abstract
Opioids are available for the management of severe and chronic pain. However, long-term use of high-dose opioids could lead to physiologic tolerance, hyperalgesia, gastrointestinal immobility, addiction, respiratory depression, tumor progression, and inhibition of the immune system. It seems some of these adverse effects of opioids might be induced by TLR-4 signaling.