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Papers of the Week

2022 Aug 27

Pharmacoepidemiol Drug Saf

Glucosamine and lower mortality and cancer incidence: Selection bias in the observational studies.


Suissa K, Hudson M, Suissa S
Pharmacoepidemiol Drug Saf. 2022 Aug 27.
PMID: 36029480.


Glucosamine is a widely used supplement to treat joint pain and osteoarthritis despite inconclusive randomized trial results on its effectiveness. In contrast, observational studies associate glucosamine with significant reductions in mortality and cancer incidence. We evaluated the extent of bias, particularly selection bias, to explain these surprising beneficial effects.