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Papers: 30 Jul 2022 - 5 Aug 2022

2022 Jul 28

Curr Opin Allergy Clin Immunol

Neuropathic pain and itch: mechanisms in allergic conjunctivitis.


Kalangara JP, Vanijcharoenkarn K, Chisolm S, Kuruvilla ME
Curr Opin Allergy Clin Immunol. 2022 Jul 28.
PMID: 35916592.


Allergic conjunctivitis is highly prevalent and affects up to one third of the general population. The current understanding of the pathophysiology and therapeutic strategies center around the type 2 inflammatory pathway. However, there is an increasing body of evidence that suggests neurogenic mechanisms also play a role in allergic inflammation, with a substantial proportion of allergic conjunctivitis patients experiencing both ocular itch and pain.