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Papers of the Week

Papers: 16 Jul 2022 - 22 Jul 2022

Animal Studies

2022 Jul 16

Arthritis Res Ther



Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain.


Itson-Zoske B, Shin S M, Xu H, Qiu C, Fan F, Hogan QH, Yu H
Arthritis Res Ther. 2022 Jul 16; 24(1):168.
PMID: 35842727.


Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (Ca3.2) regulates neuronal excitability and plays important roles in pain processing. We previously identified that enhanced T-type/Ca3.2 activity in the primary sensory neurons (PSNs) of dorsal root ganglia (DRG) is associated with neuropathic pain behavior in a rat model of monosodium iodoacetate (MIA)-induced knee OA. PSN-specific T-type/Ca3.2 may therefore represent an important mediator in OA painful neuropathy. Here, we test the hypothesis that the T-type/Ca3.2 channels in PSNs can be rationally targeted for pain relief in MIA-OA.