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Papers of the Week

Papers: 25 Jun 2022 - 1 Jul 2022

Pharmacology/Drug Development

2022 Jul 01

Korean J Pain



Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model.


Owoyele B V, Bakare A O, Olaseinde O F, Ochu M J, Yusuff A M, Ekebafe F, Fogabi O L, Roi T
Korean J Pain. 2022 Jul 01; 35(3):271-279.
PMID: 35768982.


Inflammation is known to underlie the pathogenesis in neuropathic pain. This study investigated the anti-inflammatory and neuroprotective mechanisms involved in antinociceptive effects of co-administration of acetaminophen and L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy in male Wistar rats.