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Papers of the Week

Papers: 25 Jun 2022 - 1 Jul 2022

Pharmacology/Drug Development

2022 Jun 23

Comput Biol Med


Computational approach to decode the mechanism of curcuminoids against neuropathic pain.


Xiang C, Chen C, Li XI, Wu Y, Xu Q, Wen L, Xiong W, Liu Y, Zhang T, Dou C, Ding X, Hu L, Chen F, Yan Z, Liang L, Wei G
Comput Biol Med. 2022 Jun 23; 147:105739.
PMID: 35763932.


Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are the main components of turmeric that commonly used to treat neuropathic pain (NP). However, the mechanism of the therapy is not sufficiently clarified. Herein, network pharmacology, molecular docking and molecular dynamics (MD) approaches were used to investigate the mechanism of curcuminoids for NP treatment.