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Papers of the Week


Papers: 25 Jun 2022 - 1 Jul 2022


Pharmacology/Drug Development


2022 Jun 23


Comput Biol Med


147

Computational approach to decode the mechanism of curcuminoids against neuropathic pain.

Authors

Xiang C, Chen C, Li XI, Wu Y, Xu Q, Wen L, Xiong W, Liu Y, Zhang T, Dou C, Ding X, Hu L, Chen F, Yan Z, Liang L, Wei G
Comput Biol Med. 2022 Jun 23; 147:105739.
PMID: 35763932.

Abstract

Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are the main components of turmeric that commonly used to treat neuropathic pain (NP). However, the mechanism of the therapy is not sufficiently clarified. Herein, network pharmacology, molecular docking and molecular dynamics (MD) approaches were used to investigate the mechanism of curcuminoids for NP treatment.