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Papers of the Week

Papers: 18 Jun 2022 - 24 Jun 2022

Pharmacology/Drug Development

2022 06 22

Rev Med Suisse



[Intrathecal drug delivery for chronic pain management].


Perruchoud C, Cachemaille M
Rev Med Suisse. 2022 06 22; 18(787):1254-1258.
PMID: 35735149.


Intrathecal drug delivery appeared in the early eighties and allows to administer high concentrate analgesic medications in the cerebrospinal fluid with higher efficacy and a limited incidence of systemic side effects. Opioids are still the first line treatment with high-quality evidence for chronic cancer pain, and limited evidence for chronic non-cancer pain, being often considered as a last resort therapy. Device implantation requires a strict patient's selection with a close follow-up in order to adapt therapy, refill the reservoir and detect and prevent potential severe complications.