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Papers of the Week

2022 Jun

J Surg Case Rep



Spontaneous splenic rupture from indeterminate dendritic cell proliferation: a case report.


Iqbal SB, Chittal AR, Rao SJ, Lakra P, Bhansali D, Pyrgos G
J Surg Case Rep. 2022 Jun; 2022(6):rjac211.
PMID: 35685294.


Spontaneous splenic rupture is a rare and life-threatening phenomenon, usually associated with an underlying infectious, inflammatory, hematological, neoplastic or rheumatologic condition. Indeterminate cell tumor is a rare neoplastic dendritic cell disorder that is poorly understood but shares immunophenotypic markers for Langerhans cells without Birbeck granules. A 73-year-old man presented with upper abdominal pain after an unwitnessed fall. Computed tomography angiography showed splenomegaly and a large ruptured splenic subcapsular hematoma. Intraoperative findings from an emergency laparotomy revealed a large hemoperitoneum and a ruptured spleen. Microscopic sections identified numerous, mostly poorly formed, small nodules classified as a proliferation of indeterminate dendritic cell tumors.