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Papers of the Week

2022 Jun 07

Transplant Cell Ther

The impact of pre-apheresis Health Related Quality of Life on peripheral blood progenitor cell yield and donor’s health and outcome: Secondary analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials.


Farhadfar N, Ahn K W, Bo-Subait S, Logan B, Stefanski H, Hsu JW, Panch S, Confer D, Liu H, Badawy SM, Beitinjaneh A, Diaz MA, Hildebrandt GC, Kelkar AH, Lazarus HM, Murthy H, Preussler JM, Schears RM, Sharma A, van der Poel M, et al.
Transplant Cell Ther. 2022 Jun 07.
PMID: 35688325.


There is a lack of evidence about how Health-related Quality of Life (HRQoL), including psychosocial factors, might affect donation-related experiences and clinical markers in the context of hematopoietic stem cell (HSC) donation. The broader literature suggests that psychological factors, including anxiety and depression, are associated with higher levels of inflammatory burden leading to poorer post-procedural outcomes including longer hospital stays and increased pain perception. In this study, we aimed to evaluate whether pre-donation HRQoL markers predict toxicity profile and stem cell yield following PBSC donation in healthy donors.