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Papers of the Week

Papers: 4 Jun 2022 - 10 Jun 2022

2022 Jun 01

Curr Opin Neurol



Therapies targeting CGRP signaling for medication overuse headache.


Koumprentziotis I-A, Mitsikostas DD
Curr Opin Neurol. 2022 Jun 01; 35(3):353-359.
PMID: 35674079.


Medication overuse headache (MOH) affects more than 60 million individuals worldwide causing enormous personal and social burden. Only repurposed drugs are available for MOH that share limited evidence for efficacy. The preclinical data suggesting that activation of the calcitonin gene-related peptide (CGRP) pathway is involved in headache chronification along with clinical evidence that monoclonal antibodies targeting CGRP (anti-CGRP mAbs) have good efficacy in preventing chronic migraine, triggered this review that aims to summarize the current data on the effectiveness and safety of mAbs against CGRP in MOH.