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Papers of the Week

Papers: 4 Jun 2022 - 10 Jun 2022

Human Studies, Pharmacology/Drug Development

2022 Jun 07

Eur J Pain

NRD.E1, an innovative non-opioid therapy for painful diabetic peripheral neuropathy – a randomised proof of concept study.


Tiecke E, Rainisio M, Eisenberg E, Wainstein J, Kaplan E, Silverberg M, Hochman L, Mangialaio S
Eur J Pain. 2022 Jun 07.
PMID: 35671086.


Painful diabetic peripheral neuropathy (PDPN) affects up to 26% of patients with diabetes mellitus, with major impacts on their general health and well-being. Most available drugs fail to deliver acceptable pain reduction in the majority of patients, and are often poorly tolerated. NRD.E1 is a novel product that has shown anti-nociceptive preclinical effects and good tolerability in healthy volunteer studies.