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Papers of the Week

2022 May


36 Suppl 1

The Effects of Transcutaneous Vagal Nerve Stimulation on Dynamic Cerebral Autoregulation.


Ryan CT, Pereira FG, Picking H, Schlader ZJ, Johnson BD
FASEB J. 2022 May; 36 Suppl 1.
PMID: 35553192.


Transcutaneous vagal nerve stimulation (tVNS) applied to the cervical branch of the vagus nerve is FDA-approved to treat migraine and cluster headache. tVNS applied to the auricle branch of the vagus nerve (tVNS ) reduces muscle sympathetic nerve activity and improves cardiac parasympathetic activity after one session in healthy participants. Given the use of tVNS to treat cerebral disorders and its effects on autonomic function, we postulated that tVNS might be beneficial for cerebral vascular function. We tested the hypotheses that tVNS will increase resting middle cerebral artery blood flow velocity (MCAv) and improve dynamic cerebral autoregulation (dCA) during a repeated squat-to-stand procedure.