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Papers of the Week

2022 Apr 30

Dermatol Ther (Heidelb)

Minimally Invasive Skin Transcriptome Extraction Using a Dermal Biomarker Patch.


Ibrahim SF, Taft BJ, Wang Y, Lee B-I, Andrade E, Abaya C, Pramanick S, Mannath T, Hurley KA, Mahmood TA, Dickerson TJ
Dermatol Ther (Heidelb). 2022 Apr 30.
PMID: 35488970.


Advances in the scientific understanding of the skin and characteristic genomic dermal signatures continue to develop rapidly. Nonetheless, skin diagnosis remains predicated on a subjective visual examination, frequently followed by biopsy and histology. These procedures often are not sufficiently sensitive, and in the case of many inflammatory diseases, biopsies are not justified, creating a situation where high-quality samples can be difficult to obtain. The wealth of molecular information available and the pace at which new data are acquired suggest that methods for minimally invasive biomarker collection could dramatically alter our understanding of skin disease and positively impact treatment paradigms.