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Papers of the Week

2022 Mar 30

J Pharm Pharmacol

Attenuation of opioid tolerance by ETA receptor antagonist, BQ123, administered intravenously in mice.


Bhalla S, Lyne J, Gulati A, Andurkar SV
J Pharm Pharmacol. 2022 Mar 30.
PMID: 35355073.


Intracerebroventricular injection of endothelin-A receptor antagonist BQ123 potentiates opioid analgesia and reverses analgesic tolerance. This study explores whether these effects can be replicated by injecting BQ123 intravenously.