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TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K1.1 expression in primary sensory neurons of male rats.
Abstract
Paclitaxel-induced downregulation of two-pore domain K+ channel 1.1 (K1.1) caused by increasing DNA methylation within its gene promoter in the dorsal root ganglion (DRG) contributes to neuropathic pain. Given that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) promotes DNA demethylation and gene transcription, the present study investigated whether DRG overexpression of TET1 produces an antinociceptive effect on the paclitaxel-induced nociceptive hypersensitivity.