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Papers of the Week

Papers: 19 Mar 2022 - 25 Mar 2022

Animal Studies

2022 Mar 15

Life Sci


TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K1.1 expression in primary sensory neurons of male rats.


Jia S, Wei G, Bono J, Pan Z, Zheng B, Wang B, Adaralegbe A, Tenorio C, Bekker A, Tao Y-X
Life Sci. 2022 Mar 15; 297:120486.
PMID: 35304127.


Paclitaxel-induced downregulation of two-pore domain K+ channel 1.1 (K1.1) caused by increasing DNA methylation within its gene promoter in the dorsal root ganglion (DRG) contributes to neuropathic pain. Given that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) promotes DNA demethylation and gene transcription, the present study investigated whether DRG overexpression of TET1 produces an antinociceptive effect on the paclitaxel-induced nociceptive hypersensitivity.