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Papers of the Week

Papers: 12 Mar 2022 - 18 Mar 2022

Animal Studies

2022 Mar 22

Proc Natl Acad Sci U S A



Nociception and hypersensitivity involve distinct neurons and molecular transducers in .


Gu P, Wang F, Shang Y, Liu J, Gong J, Xie W, Han J, Xiang Y
Proc Natl Acad Sci U S A. 2022 Mar 22; 119(12):e2113645119.
PMID: 35294287.


SignificanceFunctional plasticity of the nociceptive circuit is a remarkable feature and is of clinical relevance. As an example, nociceptors lower their threshold upon tissue injury, a process known as allodynia that would facilitate healing by guarding the injured areas. However, long-lasting hypersensitivity could lead to chronic pain, a debilitating disease not effectively treated. Therefore, it is crucial to dissect the mechanisms underlying basal nociception and nociceptive hypersensitivity. In both vertebrate and invertebrate species, conserved transient receptor potential (Trp) channels are the primary transducers of noxious stimuli. Here, we provide a precedent that in larvae, heat sensing in the nociception and hypersensitivity states is mediated by distinct heat-sensitive neurons and TrpA1 alternative isoforms.