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Papers of the Week


Papers: 12 Mar 2022 - 18 Mar 2022


Animal Studies


2022 Mar 22


Proc Natl Acad Sci U S A


119


12

Nociception and hypersensitivity involve distinct neurons and molecular transducers in .

Authors

Gu P, Wang F, Shang Y, Liu J, Gong J, Xie W, Han J, Xiang Y
Proc Natl Acad Sci U S A. 2022 Mar 22; 119(12):e2113645119.
PMID: 35294287.

Abstract

SignificanceFunctional plasticity of the nociceptive circuit is a remarkable feature and is of clinical relevance. As an example, nociceptors lower their threshold upon tissue injury, a process known as allodynia that would facilitate healing by guarding the injured areas. However, long-lasting hypersensitivity could lead to chronic pain, a debilitating disease not effectively treated. Therefore, it is crucial to dissect the mechanisms underlying basal nociception and nociceptive hypersensitivity. In both vertebrate and invertebrate species, conserved transient receptor potential (Trp) channels are the primary transducers of noxious stimuli. Here, we provide a precedent that in larvae, heat sensing in the nociception and hypersensitivity states is mediated by distinct heat-sensitive neurons and TrpA1 alternative isoforms.