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Papers of the Week

Papers: 12 Mar 2022 - 18 Mar 2022

Animal Studies

2022 Jan

Ann Transl Med



TNFAIP3 alleviates pain in lumbar disc herniation rats by inhibiting the NF-κB pathway.


Xie Z, Chen J, Xiao Z, Li Y, Yuan T, Li Y
Ann Transl Med. 2022 Jan; 10(2):80.
PMID: 35282077.


It's been reported that the tumor necrosis factor alpha inducible protein 3 () gene played an important role in the pathogenesis of autoimmune and chronic inflammation diseases. Moreover, in degenerative diseases of the lumbar spine the nuclear factor-κB (NF-κB) pathway is significantly activated. This study aimed to explore the role of the tumor necrosis protein-induced zinc finger protein A20 (A20) protein in degenerative diseases of the lumbar spine on the NF-κBp65 pathway.